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COVID may activate dormant bacterial infections, tuberculosis: research

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The results detailed in The American Journal of Pathology may pave the way for new vaccines against infectious diseases and avoid potential global TB epidemics.

According to one study, the SARS-CoV-2 virus that causes COVID-19 may have the ability to reactivate dormant tuberculosis (TB). This is alarming news for a country like India, which accounts for an estimated 40% of the population with latent tuberculosis infections.

The study, led by researchers at the Indian Institute of Technology (IIT), Guwahati, and the University of Massachusetts, showed that infection with certain coronavirus strains reactivates dormant tubercle bacilli (MTB) in mice.

The results detailed in The American Journal of Pathology may pave the way for new vaccines against infectious diseases and avoid potential global TB epidemics.

“The discovery of tuberculosis reactivation in a stem cell-mediated Mtb dormant mouse model during MHV-1 coronavirus infection indicates that SARS-CoV-2 virus may activate dormant bacterial infection in the long term after a pandemic. This is an important finding given the current coronavirus epidemic, and many dormant tuberculosis-infected vectors in India and other developing countries have an increased number of cases of active tuberculosis after COVID-19. It’s possible, “explained Bikul Das, senior researcher in the stem cell division. And Infectious Diseases, Kavi Krishna Institute, IIT-Guwahati.

“There is an urgent need to study the link between COVID-19 and dormant tuberculosis reactivation to avoid a potential pandemic of tuberculosis,” Das added.

The team studied coronavirus strain murine coronavirus-1 (MHV-1) infection in the lung in a mouse model of MTB dormancy (dMtb) mediated by mesenchymal stem cells (MSC). By the third week of viral infection, this showed a 20-fold lower viral load than dMtb-free control mice and a 6-fold increase in altruistic stem cells (ASC), thereby enhancing protection.

Tuberculosis is reactivated in dMtb mice, suggesting that dormant M. tuberculosis hijacks these ASCs and replicates in the lung, causing pulmonary tuberculosis. The results suggest that these ASCs are transient (expand for 2 weeks and then undergo apoptosis or cell suicide) and exhibit antiviral activity against MHV-1 by secreting soluble factors. I will.

“To develop better vaccines and treatments, it is important to understand the host’s defense mechanism against this disease. Therefore, like bacteria, adult stem cells are also altruistic, protecting the niche from external threats. I’ve assumed that it could show a good defense mechanism, “Das said.

COVID may activate dormant bacterial infections, tuberculosis: research

Source link COVID may activate dormant bacterial infections, tuberculosis: research

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