Santé

Higher antibiotic doses may overcome drug resistance, but may enhance certain bacteria-Health News, Firstpost

Antimicrobial resistance is projected to cause 10 million deaths annually by 2050.

Antibiotic-resistant superbugs are predicted to kill more people around the world than cancer by the middle of the century, and more about how higher doses affect the long-term evolution of bacteria. A lot of research was needed.

High doses of antibiotics may enhance certain bacteria to address the problem of increasing drug resistance, according to a previously unthinkable risk-enhancing study published Wednesday. there is. Antimicrobial resistance has been labeled by the United Nations as “one of the greatest threats we face as a global community” and is projected to kill 10 million people each year by 2050. To develop resistance, yet little attention is paid to how those higher doses affect the overall health of the microorganism.

A team of researchers based in the United Kingdom and Europe investigated how a population of E. coli responds to different concentrations of three common antibiotics.

They found that high doses of antibiotics slowed the rate at which bacteria developed resistance, while producing “overall fitness” bacteria. In other words, the breeding rate is high.

“Growth rates are considered a substitute for fitness, assuming that fast-growing strains are likely to take over and dominate the population,” said Mato Lagator, lead author of the University of Manchester’s Department of Life Sciences. I’m doing it. ” AFP..

The team behind the research published in the journal Royal Society of Biology LetterSaid, it showed how higher antibiotic doses could present a “dilemma” and ultimately result in more resistant bacteria.

“Given the fitness of evolved strains, there is another dimension to the problem of optimal antibiotic administration,” they write.

trade off

Several recent studies have warned of the risk of over-prescribing antibiotics and over-use of livestock, and the US Centers for Disease Control and Prevention estimates that one-third of antibiotic prescriptions are unnecessary. I am.

“New drugs are usually developed with one major focus on how well they get rid of the infection,” Lagator said.

“Rarely considered is the potential for target bacteria to evolve resistance to those drugs and the fitness of resistant strains that may emerge.”

Antibiotic-resistant superbugs are predicted to kill more people around the world than cancer by the middle of the century, and Lagator tells us how high doses affect the long-term evolution of bacteria. , Said that more research is needed.

“Personally, I say that focusing on immediate rewards, that is, increasing drug efficacy at high doses, without understanding the long-term consequences, can cause problems. “I will.”

“There are trade-offs here that are complex and require further investigation. Our fairly simple studies have shown that resistance develops slowly at high doses, but then those strains are generally good. Become.”

Higher antibiotic doses may overcome drug resistance, but may enhance certain bacteria-Health News, Firstpost

Source link Higher antibiotic doses may overcome drug resistance, but may enhance certain bacteria-Health News, Firstpost

Back to top button