Recent studies have established links between Covid-19 and many diseases. These include deregulation of the innate immune system and changes in the gut microbiome. These mechanisms were described as early as his March and published by Jean-Marc Sabatier* in April 2020.
A study published Nov. 9 in Journal of Medical Virology We are trying to unravel the mystery of Covid-long, which affects about 2 million people in France. A study conducted by Alan Thierry’s team insert researcher At the Cancer Institute in Montpellier, “underscoring the possible deregulatory role of some of the innate immune defenses.”
Researchers have tracked the generation of ‘extracellular neutrophil traps’ (proliferation of these = neutrophilia), the first-line defense mechanism against pathogens, which can be It may be involved in the persistence of symptoms after menopause. Severe form of Covid-19. “These extracellular traps can, in some cases, cause excessive inflammation that is harmful to the body.”
According to Alain Thierry, midi libre: “Their activation is associated with a series of microthromboses of the heart, especially blood vessels, and inflammation characteristic of long-term Covid-related pathologies, comorbidities well known to physicians: phlebitis, arterial thrombosis, It leads to arthritis, hypertension…”
Alain Thierry and his team filed a patent for a blood test to identify these markers last August, Montpellier adds daily.
Another study published in Nature Communications reprinted in Science et Avenir On November 8, 2022, it was revealed that Covid-19 infection directly disrupts the gut microbiome. “In severe Covid-19, a flora imbalance can lead to bacterial superinfection…Antibiotics used as a preventive measure to avoid nosocomial infections in hospitalized patients, SARS-CoV-2 There are well-known effects of microbiota abnormalities that may amplify that of .
“We are the first to detect an effect on epithelial cells[of the intestinal wall]and show that antibiotics can exacerbate the situation,” said Lucy, lead author of the study. Bernard Lyon says. (…) It has therefore been observed that infection is induced indirectly, probably by overactivation of the immune response. ”
a fundamental discovery
These two studies confirm what Jean-Marc Sabatier found two and a half years later in a study published in April 2020.
The renin-angiotensin system (RAS) is the ‘real’ culprit of Covid-19 and SARS-CoV-2 is the oil to light the fire,” he explained on infodujour.fr.
RAS is responsible for ‘Covid-19-like’ diseases through overactivation of its ‘harmful’ receptor, AT1R. This hyperactivated RAS receptor subverts the innate immunity it drives, primarily resulting in vasoconstriction/hypertension, inflammation, oxidative stress, hypoxia, angiogenesis, thrombosis, nitric oxide depression, hypertrophy, and induce organ fibrosis. It is the cause of macrophage activation syndrome (causing hemophagocytosis, ie, attack on red blood cells, white blood cells, and platelets) and mast cell activation syndrome.
This ‘harmful’ effect of dysfunctional RAS can affect many organs and tissues in our body, including hypertension, atherosclerosis, hypertrophy (heart, lungs, etc.), organ fibrosis. (heart, lung, kidney, liver, heart failure, kidney and lung damage (including acute respiratory distress syndrome, asthma), anaphylaxis, and other disorders) and organ fibrosis (heart, lung, kidney, liver), heart failure , kidney and lung disorders (including acute respiratory distress syndrome and asthma), anosmia (loss of smell), anesthesia (loss of taste), neuropathy/memory impairment, diarrhea, bowel and vascular inflammation, lipid metabolism disorders, Effects on obesity and glucose metabolism (type 2 diabetes), thrombosis/coagulopathy, skin and testicular damage.
Furthermore, ‘deregulated’ RAS has been implicated in the induction of cognitive/neurological disorders, cancer, and other autoimmune diseases (such as multiple sclerosis and rheumatoid arthritis) through effects on the central nervous system, cells. It seems that there is a possibility that Proliferation and adhesion, and ‘natural’ immunity.
Read his full interview below.
Scientists working on Covid-19 are studying the effects of the RAS and its dysfunction, leading to hyperactivation of the harmful receptor, AT1R, which further elucidates the origins of the Covid-19 (and longer Covid) pathology. Well understand and fix them.
*Jean-Marc Sabatier, Research Director, CNRS, PhD in Cell Biology and Microbiology, HDR in Biochemistry. Editor-in-chief of the international scientific journals “Coronaviruses” and “Infectious Disorders – Drug Targets”. He speaks by his own name here.
https://frenchdailynews.com/health/5599-covid-19-new-discoveries-already-described-in-2020 “New discoveries” already described in 2020