The opposite effect of vaccine boosters

A recent study from the Cleveland Clinic aimed at finding out whether a bivalent vaccine protects against Covid-19 was described by Jean-Marc Sabatier* in the August 2021 article “The Risks of a Third Dose”. It confirms that. explanation.

Research published in “preprints” MedRxiv website Entitled “Efficacy of Bivalent Vaccine” [coding for two distinct spike proteins] Against Covid-19 Disease” has been the subject of much ink since it was published in December 2022. Pro- and anti-vaccination groups have battled it out on the internet with often unconvincing arguments. what up?

higher risk

Cleveland Clinic It is an American university medical center based in Ohio. It is regularly ranked as one of the best in the U.S. A team of researchers hope to assess the effectiveness of his bivalent vaccine used as a booster dose to fight Covid-19. I was. The study involved 51,011 clinic employees, who were observed for 13 weeks after vaccination.
The study states that both innate and vaccine-induced immunity protect against COVID-19, but both forms of immunity weaken over time. It is the measurement of an individual’s immunity over time after inoculation.

For researchers, the arrival of the Omicron variant in December 2021 has changed the immune defense landscape. Previously infected or vaccinated individuals are no longer protected from COVID-19.

Enlightening graphs!

To confirm their research, researchers create graphs. they wrote: The more vaccinations you have, the higher your risk of contracting SARS-CoV-2 and COVID-19.

They said: Point estimates and 95% confidence intervals are halved along the x-axis for better visibility. “

“Facilitation” Antibodies

This is exactly what Jean-Marc Sabatier suggested in an article published on 11 August 2021. notice, a censored article, but available at contre-pouvoir.info. What did Jean-Marc Sabatier say?

There are several types of antibodies.

• “Neutralizing” antibodies that fight and neutralize viruses. These are the ones most familiar to the general public. Their production is desired during vaccination.
• A neutral ‘antibody that recognizes, but does not protect, the SARS-CoV-2 spike protein involved in cell infection.
• A “promoting” antibody that promotes infection of a cell by a virus, as opposed to a “neutralizing” antibody. These are antibodies that must be avoided during vaccination. However, all current vaccines are based on the SARS-CoV-2 spike protein and produce these three types of antibodies. Hence the difficulties seen after vaccination in some patients. Therefore, the recommended booster-shot vaccination strategy, including in France, for patients suffering from comorbidities (obesity, diabetes, hypertension, etc.) is also of concern.

in a previous articlewe certainly saw it FIP coronavirus Feline infectious peritonitis showed strong similarity to the coronavirus SARS-CoV-2, the cause of Covid-19 in humans. We also found that attempting to vaccinate a cat with an avirulent strain of her FIP not only failed to protect the vaccinated cat, but conversely, conversely, infection in cats subsequently exposed to a virulent strain of FIP virus. and promote mortality.

treatment is worse than the disease

These data indicate the presence of (in this case) A Phenomenon Called “ADE” (Antibody-dependent enhancement). In this mechanism there are “promoting” antibodies. These antibodies bind to her FIP virus, facilitating infection of cells by the virus. Indeed, phagocytic cells (monocytes, macrophages, dendritic cells, etc.) have receptors (termed FcgRIIa) that can recognize antibodies bound to virus particles, and internalization of virus-antibody complexes results in these cells can be infected.
ADEs in respiratory infections fall under a broader category called ERD (“enhanced respiratory disease”). ERD also includes non-antibody-based mechanisms (such as cytokine storm and cell-mediated immunopathology) that drive the infectious process and deleterious effects. virus.
It was clearly observed that people who received a booster vaccine were more likely to become infected with SARS-CoV-2 than those who did not receive the booster vaccine.

The ‘ADE’ (or ‘ERD’) phenomenon is present in current SARS-CoV-2 variants. These multiple booster shots seem to increase the proportion of “promoting” antibodies, having the opposite effect of what was intended.

*Jean-Marc Sabatier, Research Director, CNRS, PhD in Cell Biology and Microbiology. He is editor-in-chief of the international scientific journals “Coronaviruses” and “Infectious Disorders – Drug Targets”. he’s speaking for himself here.