The Surprising Role of SRA

As a true visionary, Jean-Marc Sabatier* emphasizes the critical role of the renin-angiotensin system in the development of numerous medical conditions. Little known until now, “This hormonal system is everywhere and controls everything,” he says.

Jean-Marc Sabatier (DR)

What is the renin-angiotensin system (RAS) and do you claim that its dysfunction is the cause of many diseases?

It is the most important physiological regulatory system in our body. Controls autonomic, renal, pulmonary, and cardiovascular functions. It also regulates innate immunity and various microbiota, including the gut microbiota. It is a cascade of endocrine and enzyme regulation. This ubiquitous system is found in all organs and tissues of the human body.

You were the first to show that a dysfunctional RAS is the origin of the Covid-19 disease.What’s new today

In fact, we find that all medical conditions in the human body, if not related to genetic abnormalities, result from the malfunctioning of this vital system of the organism. To understand it, we need to take into account the genetic polymorphisms of the actors (ligands and receptors) of the RAS, their evolution over a person’s lifetime (her RAS in a baby is her RAS in a child, her RAS in an adult). is different). and the elderly), evolving from birth to death. Being ubiquitous in the body at the level of organs, tissues and cells, it controls all functions related to cell life. What is new is this global ‘vision’ of her RAS’ importance not only in total control of the human body, but also in potential triggers of various pathologies. Researchers will surely discover the extreme importance of RAS little by little. This hormonal system was misnamed because it was initially identified in the kidney and liver (hence the name), but is eventually present in all organs. control all important functions of
Binding of the coronavirus SARS-CoV-2 (or spike protein) to the cellular receptor ACE2 (angiotensin-converting enzyme 2) prevented the degradation of angiotensin 2 by ACE2 and excessively induced overactivation of the cellular receptor AT1R. increase. Excessive activation of RAS has a very detrimental effect on the organism, especially leading to the development of her COVID-19 disease. AT1R receptors include vasoconstriction (hypertension), pro-inflammatory (cytokine storm), pro-thrombosis, pro-fibrogenesis, pro-oxidant (causing oxidative stress), pro-angiogenic, hypertrophic organs (heart, lung etc.), inhibitory there is. The production of nitric oxide (NO), which affects the immune and nervous system… So his over-activated AT1R receptor (= RAS dysfunction) is the real culprit of Covid-19 disease.

This is a visionary approach to science…

Yes, I expect that what I think will only become apparent to researchers over decades of large-scale studies is the development of autoimmune diseases and cancers (excluding genetic diseases) due to RAS dysregulation. All these diseases have one thing in common. It is a ubiquitous RAS. It is the key to all non-genetic pathologies, the conductor of the human body’s functions, and not the brain as we still believe today, as the brain itself is controlled by his RAS. Controls the functions of neurons and other cells in the nervous system. It is the supreme leader in our organism. This central role of RAS is still unknown today. Given the complexity of this hormonal system and the relative slowness of scientific progress in this area of ​​research, we will probably find out in the coming decades.

How do you come to this conclusion?

This hormonal system is everywhere. Thus, they are ubiquitous in various tissues and organs of the human body, including within cells with intracrine activity. For example, in cells, RAS is found in the inner membrane of mitochondria, the nuclear membrane, and other membranes of intracellular organelles, so there are no known equivalents in other physiological systems. Why are RAS all over the body? Because they rule everything. it should be everywhere.
It should be noted that there are also variants of RAS that correspond to adaptations of this system to specific functions of organs. For example, her RAS in the heart is not the same as RAS in the lungs. There are also specific RASes in the brain, gut, etc. The same receptors and ligands are always involved, but their proportions and tissue distribution are not the same. Therefore, local RAS adapts to organ function. As such, we have our fingers on the major systems that control the entire human body. And finally, no one has identified it yet!

Does taking into account RAS dysfunction allow better treatment of RAS-induced pathologies?

Solving the problems associated with RAS dysfunction would allow a wide variety of (non-genetic) medical conditions in humans, including neurological diseases (Alzheimer’s disease, Parkinson’s disease, etc.) and autoimmune diseases (multiple sclerosis, rheumatoid arthritis, etc.). It is theoretically possible to treat ), cancer (RAS regulates cell proliferation), etc. In my opinion, its involvement in the functioning of the human body goes far beyond what is currently described. It tells me today that its ubiquity in subcellular organelles, including mitochondria, indicates that it represents a key to cell function, and that it is probably the origin of all non-genetic pathologies. RAS is also implicated in individual longevity. In particular, it affects DNA repair and the integrity of telomeres (structures at the ends of chromosomes involved in longevity).

How can I target it?

Currently, medicine primarily treats the consequences, not the causes of disease. To cure various human pathologies (and mammalian pathologies in general), whatever its nature, in my opinion the renin-angiotensin system should be targeted. It should be possible to modulate the potentially detrimental effects of modified RAS on organisms.
I would like to emphasize the importance of this research tool, which is still largely unknown. Because I am confident that in the coming decades, researchers will identify an important role for her RAS in body function and related pathologies. I strongly encourage researchers and physicians to take an interest in this area of ​​unexpected potential, especially in therapeutics. should lead to progress.

*Jean-Marc Sabatier is Research Director at CNRS and holds a PhD in Cell Biology and Microbiology and an HDR in Biochemistry. He is editor-in-chief of the international scientific journals “Coronaviruses” and “Infectious Disorders – Drug Targets”. he speaks by his own name.

Covid-19 and Vaccines: A Video to Understand It All The Surprising Role of SRA

Back to top button